The Missouri Botanical Garden in St. Louis, Missouri, is one of the oldest and most renowned botanical gardens in the United States. Established in 1859 by philanthropist and botanist Henry Shaw, it is often referred to as "Shaw's Garden" and serves as a leading center for botanical research, education, and conservation.

St. Louis is a city in Missouri, on the western bank of the Mississippi River, which forms the state line between Illinois and Missouri. St. Louis' 2019 population was at 300,576.