Homosassa is a census-designated place in Citrus County, Florida. The population was 2,299 at the 2020 census. Homosassa, about 75 miles north of Tampa in West Central Florida, is a water-lover’s paradise. Home of manatees, spring-fed rivers, waterfront resorts and restaurants, and some of the best scalloping spots in Florida, Homosassa is an ideal family-friendly fishing and outdoor destination.